Dual GIP and GLP-1 mechanism

Two receptors, one metabolic reset

With the structure understood, this unit follows the signal inward. Tirzepatide activates the GIP and GLP-1 receptors on pancreas, brain, gut, and fat, and the effects add up: more insulin when it is needed, less glucagon, a quieter appetite, and better-behaved fat tissue.

You will see where in the body it acts, how the beta-cell responds, and why combining two incretin signals does more than either alone.