Stabilization: the hexenoyl cap and DPP-4 resistance

One chemical change that turns minutes into a usable daily drug

Native GHRH and sermorelin are cleared within minutes because a blood enzyme clips their N-terminus. Tesamorelin solves this with a single addition: a trans-3-hexenoyl group on the first residue that shields the cleavage site.

This unit walks the exact bond that DPP-4 attacks, how the fatty-acid cap blocks it, how much half-life that buys, how it compares with other stabilizing strategies, and where compounded-product quality can slip.