Tesamorelin mastery course
Unit 7 of 11

Liver fat: the NAFLD evidence

The best-supported use beyond the label is fatty liver in HIV. Two randomized trials show tesamorelin meaningfully redu…

The promising second act: reducing liver fat, still off-label

The best-supported use beyond the label is fatty liver in HIV. Two randomized trials show tesamorelin meaningfully reduces liver fat, and a biopsy substudy hints it slows disease progression, all through the same visceral-fat mechanism.

This unit covers the pathobiology of HIV-associated fatty liver, the Stanley 2014 and 2019 trials, the visceral-to-liver mechanism, and why strong data in a narrow population is still not the same as an approved indication.

Key terms

Why the HIV liver stores fat


Stanley 2014: proof of concept


Stanley 2019: the confirmation


The visceral-to-liver link


Strong data, still off-label