molecular structure

43 Amino Acids, Three Domains

TB-500 derives its activity from the full 43-amino-acid sequence of thymosin beta-4, beginning with the N-acetylated Ac-SDKP tetrapeptide. the peptide contains three functionally distinct domains: the N-terminal signaling region, the central LKKTET actin-binding motif, and the C-terminal regulatory tail. understanding these domains explains why TB-500 can influence such a wide range of biological processes.