anti-inflammatory mechanisms

NF-kB suppression, cytokine modulation, and oxidative stress reduction in TB-500 research

Dampening the Inflammatory Cascade

inflammation is essential for initiating wound repair, but prolonged or excessive inflammation destroys tissue and delays healing. TB-500's anti-inflammatory activity centers on suppressing NF-kB nuclear translocation -- the master switch that activates transcription of pro-inflammatory genes. in animal models, this translates to reduced levels of TNF-alpha, IL-1beta, and IL-6, along with decreased matrix metalloproteinase (MMP) activity that would otherwise degrade newly formed tissue.

Interactive Inflammation Map

Explore the inflammatory pathways modulated by TB-500.

inflammation pathway map

Knowledge Check

Test what you've learned in this unit.

Practice Exercises

Reinforce your understanding.