actin biology

The Actin Connection

the single most important function of thymosin beta-4 -- and by extension TB-500 -- is its ability to sequester G-actin monomers. in every nucleated cell, Tb4 maintains a reservoir of unpolymerized actin that can be rapidly deployed when the cell needs to move, divide, or change shape. this G-actin buffering system is the foundation of TB-500's effects on wound healing, cell migration, and tissue repair.