Sermorelin mastery course
Unit 3 of 11
The GHRH receptor
Everything sermorelin does begins at one place: the GHRH receptor on pituitary somatotropes. It is a class B G-protein-…
One receptor, a cAMP cascade, and the biology of a single GH pulse
Everything sermorelin does begins at one place: the GHRH receptor on pituitary somatotropes. It is a class B G-protein-coupled receptor that turns a binding event into a burst of cAMP and, moments later, a pulse of growth hormone.
This unit follows the signal from receptor to released hormone, explains why the pituitary transcription factor Pit-1 matters, and shows why intermittent dosing keeps the receptor responsive while continuous stimulation blunts it.