Sermorelin mastery course
Unit 4 of 11
The GH and IGF-1 axis
A GH pulse is only the middle of a longer story.
From a pituitary pulse to IGF-1, and back again through feedback
A GH pulse is only the middle of a longer story. Growth hormone acts on the liver, which makes IGF-1, and IGF-1 then feeds back on the hypothalamus and the pituitary to keep the whole system in bounds.
This unit maps the axis across the body, follows GH to IGF-1, unpacks the feedback loops that make sermorelin self-limiting, and shows why the biggest natural pulse is tied to slow-wave sleep.