Chemistry & pharmacokinetics

The structure, the half-life, and the puzzle in between

Semax is a small, linear peptide, but its pharmacokinetics hold a genuine puzzle: it vanishes from the blood within minutes yet its effects last for hours or days. That mismatch shapes how the whole field thinks about it.

This unit covers the sequence and molecular identity, the metal-free layout of the chain as it is supplied, the intranasal route, the rapid degradation, and the leading explanations for why such a short-lived peptide acts for so long.