The GLP-1 Pathway
Appetite suppression, insulin secretion, and gastric emptying
The Appetite Brake
The GLP-1 receptor is the foundation of modern obesity pharmacotherapy. Semaglutide proved that activating this single receptor could produce clinically meaningful weight loss. Retatrutide shares this mechanism but layers two more on top. This unit breaks down exactly how GLP-1 receptor activation suppresses hunger, delays stomach emptying, and fine-tunes insulin release -- the effects that all three drug classes have in common.
Trace the GLP-1 Signaling Cascade
Follow the signal from receptor binding through cAMP production to appetite suppression, insulin release, and gastric slowing.