PT-141 mastery course
Unit 2 of 11

The melanocortin system

PT-141 makes no sense without the receptor family it targets. The melanocortin system starts from a single prohormone,…

One prohormone, five receptors, and why MC4R is the sexual-circuit hub

PT-141 makes no sense without the receptor family it targets. The melanocortin system starts from a single prohormone, POMC, and signals through five receptors (MC1R to MC5R) that each run a different job, from skin pigment to adrenal hormones to appetite.

This unit walks that system, shows where MC4R sits in the brain, and explains the knockout and cross-drug evidence that makes MC4R the receptor behind PT-141 sexual effects rather than a lucky guess.

Key terms

From one prohormone to many signals


Five receptors, five jobs


Where MC4R sits in the brain


The knockout evidence


A second MC4R drug confirms the story