PT-141 mastery course
Unit 4 of 11

The central mechanism

This is where PT-141 earns its identity. It acts centrally on MC4R-bearing hypothalamic neurons, and animal work…

How a brain receptor turns into oxytocin, dopamine, and felt desire

This is where PT-141 earns its identity. It acts centrally on MC4R-bearing hypothalamic neurons, and animal work points at oxytocin and dopamine as the signals that carry the effect forward.

The unit follows that signal from receptor to behavior, contrasts it once more with the vascular PDE5 route, and explains how one receptor can drive desire in women and erection in men through a shared upstream circuit.

Key terms

Central versus peripheral, one more time


From receptor to second messenger


Two neurochemical arms


Human brain-imaging evidence


One receptor, sex-specific outputs