melanotan ii mastery course
Unit 2 of 11
receptor pharmacology and selectivity
why hitting four receptors at once creates effects you didn't ask for
non-selective binding is the story
Melanotan II's defining pharmacological feature is that it does not pick a single melanocortin receptor. it activates MC1R, MC3R, MC4R, and MC5R with meaningful affinity. that non-selectivity is responsible for both the tanning effect and every off-target consequence that follows.
interactive receptor binding map
explore how MT-II distributes its binding across four melanocortin receptor subtypes and what each receptor mediates.
receptor binding map