Immunomodulation & chemotaxis

The peptide that tells immune cells where to go

LL-37 does far more than kill microbes. It is a signal: acting through the receptor FPR2 (also called FPRL1), it chemoattracts neutrophils, monocytes, and T cells, bridges the innate and adaptive immune systems, and tunes how strongly inflammation runs.

This unit follows LL-37 as an immune conductor: the receptor it uses, where in the body it acts, the cells it recruits, and the crucial double role of both amplifying and resolving inflammation. That two-way influence is why LL-37 is central to both defense and to diseases of misfired immunity.