The clinical evidence

What the human and animal studies actually found

This is the unit where enthusiasm meets the record. Ipamorelin has one rigorous human pharmacokinetic study, one published Phase II efficacy trial, a second and larger Phase II that finished in 2014 and was never reported, and a handful of preclinical animal studies. That is the whole serious dataset, and it tells a more sobering story than the marketing.

We walk the Phase I pharmacokinetics, the negative postoperative-ileus trial that is the only efficacy test ever published, the unpublished sibling trial that sits beside it, the preclinical bone and growth work, and how to place all of it on an honest evidence hierarchy. The headline: strong pharmacology, one failed outcome trial, one silent one, no approved use.