Mechanism of Senescent Cell Elimination

From binding competition to selective apoptosis, step by step.

the apoptosis cascade

FOXO4-DRI works by competing with endogenous FOXO4 for p53 binding, releasing p53 from nuclear sequestration and allowing it to activate the intrinsic apoptosis pathway. This unit traces each step of that cascade from initial binding competition through caspase activation.

Apoptosis Pathway Map

Follow the step-by-step cascade from FOXO4-DRI binding through mitochondrial outer membrane permeabilization and caspase activation.

apoptosis pathway map

Knowledge Check

Test your understanding of the FOXO4-DRI mechanism and the apoptosis cascade.

Practice

Reinforce the mechanistic steps before reviewing the preclinical evidence.