FOXO4-DRI mastery course
Unit 4 of 11
Senolytic mechanism: selective apoptosis
A senolytic is only useful if it is selective: it must kill senescent cells while leaving healthy ones intact.
Why the same peptide kills one cell and spares another
A senolytic is only useful if it is selective: it must kill senescent cells while leaving healthy ones intact. FOXO4-DRI does not get there through targeted delivery. The difference is in the cells: FOXO4 rises as a cultured fibroblast becomes senescent, so there is far more of the interaction for the decoy to break.
This unit examines how competitive displacement produces apoptosis, why the effect is concentration-dependent, and where the selectivity story is strong versus where it is still an assumption.