foxo4-dri mastery course
Unit 2 of 11
The FOXO4-p53 Survival Axis
How one protein partnership keeps zombie cells alive.
why senescent cells refuse to die
Senescent cells accumulate because they actively suppress their own death. The central mechanism is a nuclear interaction between FOXO4 and p53 that traps the cell's most powerful pro-apoptotic factor in a location where it cannot trigger cell death. This unit dissects that partnership.
FOXO4-p53 Binding Explorer
Visualize how FOXO4 sequesters p53 in nuclear foci and what happens when that interaction is disrupted.
foxo4-p53 binding explorer