FOXO4-DRI mastery course
Unit 2 of 11
The FOXO4-p53 axis
Senescent cells are packed with damage that should trigger their own death, yet they survive. The reason is a specific…
The molecular handcuff that keeps zombie cells alive
Senescent cells are packed with damage that should trigger their own death, yet they survive. The reason is a specific protein-protein interaction: elevated FOXO4 physically grabs p53 and holds it in the nucleus, blocking the death signal from ever reaching the mitochondria.
This unit unpacks that handcuff, the axis FOXO4-DRI was designed to break, and the experiments that proved it is real rather than merely plausible.