FOXO4-DRI mastery course
Unit 2 of 11
The FOXO4-p53 axis
Senescent cells are packed with damage that should trigger their own death, yet they survive.
The molecular handcuff that keeps zombie cells alive
Senescent cells are packed with damage that should trigger their own death, yet they survive. The reason is a specific protein-protein interaction: elevated FOXO4 physically grabs p53 and holds it in the nucleus, blocking the death signal from ever reaching the mitochondria.
This unit unpacks that handcuff, the axis FOXO4-DRI was designed to break, and the experiments that proved it is real rather than merely plausible.