Preclinical Evidence: Aging and Chemotoxicity

The mouse studies that started the FOXO4-DRI story.

the landmark experiments

The 2017 Baar et al. paper in Cell provided the first in vivo evidence that FOXO4-DRI could selectively clear senescent cells and restore tissue function in aging mice. This unit examines what those experiments actually showed and where the evidence remains limited.

Preclinical Results Dashboard

Compare key outcomes across the original aging and chemotoxicity mouse experiments.

preclinical results dashboard

Knowledge Check

Test your understanding of the Baar et al. study design and key findings.

Practice

Reinforce the preclinical evidence base before exploring disease-specific models.