FOXO4-DRI mastery course
Unit 5 of 11

Aging & animal models

The images that made FOXO4-DRI famous came from mice: aged animals that regrew fur, recovered grip strength, and improv…

The mouse experiments that started it all

The images that made FOXO4-DRI famous came from mice: aged animals that regrew fur, recovered grip strength, and improved kidney markers after a few pulses of peptide. These are the results everyone quotes, so it is worth examining exactly what was done, what was measured, and what the experiments do and do not prove.

This unit walks through the Baar 2017 aged-mouse work in detail, honestly separating the genuinely impressive from the frequently over-stated.

Key terms

What improved in the aged mice


The functional numbers


The experimental protocol


Three models, one signal


What the mouse data does not show