dsip mastery course
Unit 6 of 11
other applications
withdrawal, pain, antioxidant -- reading the evidence honestly
the largest DSIP dataset -- and its limits
Beyond sleep and stress hormones, DSIP has been studied in alcohol and opiate withdrawal, pain management, and antioxidant protection. The withdrawal cohort (n=107 inpatients, Dick 1984) is the largest human DSIP dataset, but it falls short of modern RCT standards. The pain data is contradictory between studies. The antioxidant findings are real but almost entirely from rodent models from specific research groups, with limited independent replication outside that body of work.
n=107
withdrawal cohort (Dick 1984)
47 alcohol
withdrawal subgroup
60 opiate
withdrawal subgroup
mixed pain data
naloxone-sensitivity contested
rodent antioxidant
primary evidence base
limited replication
across independent groups
evidence map
Map DSIP's evidence quality across withdrawal, pain, antioxidant, and aging claims.
evidence quality map