Dihexa mastery course
Unit 3 of 10
The HGF/c-Met hypothesis
Dihexa's headline mechanism is that it potentiates hepatocyte growth factor signaling at the c-Met receptor, driving…
The proposed mechanism, and why it is a hypothesis
Dihexa's headline mechanism is that it potentiates hepatocyte growth factor signaling at the c-Met receptor, driving the growth of new synapses. It is a genuinely interesting idea, and its defining paper was retracted in 2025.
This unit separates the well-established background biology of HGF and c-Met from the specific, and now shakier, claim that dihexa harnesses it. It also revisits the older AT4 receptor framework: the same laboratory described the receptor, and another group later identified it as the enzyme IRAP.