Pulsatile versus sustained GH

A rhythm amplified, or a baseline raised

Growth hormone is naturally released in pulses, sharp bursts separated by quiet troughs, and pulsatile secretion is considered important for many of the hormone's effects. Only one of the two CJC-1295 variants has been measured against it: a single injection of the DAC version raised the GH trough 7.5-fold while leaving pulse frequency and amplitude unaltered. What the no-DAC version does to the rhythm is unknown: FDA's 2024 review found no pharmacology study of it at all.

This unit builds the rhythm carefully, because it is where a genuinely surprising finding sits: even under the continuous stimulation of the DAC variant, the natural pulsing did not disappear. It also keeps the pulsatile case for the no-DAC form where it belongs, as an argument from GHRH physiology rather than a finding about that molecule.