tb-500 mastery course
Unit 6 of 12

wound healing & tissue repair

dermal repair, musculoskeletal healing, and hair follicle regeneration in TB-500 animal studies

from bench to bandage

tb-500's unique hook is actin sequestration -- thymosin beta-4 binds g-actin monomers and releases them on demand, powering the cell migration that rebuilds a wound bed.

Since Malinda 1999, animal studies show faster closure and smaller scars across dermal, corneal, tendon, and bone models.

~42%
faster re-epithelialization (Malinda 1999, rat)
25-30%
faster closure in db/db diabetic mice (Philp 2004)
0
RCTs in humans with injectable TB-500

the four phases of wound healing

where TB-500 acts across the repair timeline.

1. hemostasis
minutes -- platelets release TB4 locally
2. inflammation
hours-days -- TB4 dampens NF-kB
3. proliferation
days-weeks -- keratinocyte migration via actin + Ac-SDKP
4. remodeling
weeks-months -- organized collagen, smaller scars

where TB-500 acts across the wound-healing timeline

click a phase to see the tb-500-specific molecular role.

four phases of wound healing

interactive evidence dashboard

browse the wound healing evidence by tissue type and study.

wound healing evidence dashboard

Rodents close dorsal wounds mostly by contraction (panniculus carnosus). Humans close them by re-epithelialization, so a 42% rat-contraction signal is not a 42% human-closure signal -- which is why RGN-259 targets cornea instead, where the species gap is smaller.