Dosing & Administration
Titration schedule, injection technique, storage, and monitoring
Practical Dosing
Retatrutide is administered as a once-weekly subcutaneous injection with a gradual dose escalation to manage GI tolerability. The Phase 2 trial tested four dose tiers (1mg, 4mg, 8mg, 12mg) with a structured titration that started low and increased every four weeks. This unit covers the practical side: how to titrate, where to inject, how to store, and what to monitor.
Titration Schedule
Dose escalation protocol from Phase 2: starting dose through maintenance.
Injection Technique
Subcutaneous injection sites, rotation, and administration best practices.
Storage & Handling
Temperature requirements, light sensitivity, and shelf life considerations.
Timeline to Effects
Expected onset of appetite suppression, weight loss milestones, and plateau phases.
Monitoring Schedule
Lab work, vital signs, and clinical checkpoints recommended during treatment.