LL-37 mastery course
Unit 9 of 12
Therapeutic development & delivery
LL-37 looks like an ideal drug on paper and behaves like a difficult one in practice. It is degraded by proteases, weak…
Why a promising peptide is so hard to turn into a drug
LL-37 looks like an ideal drug on paper and behaves like a difficult one in practice. It is degraded by proteases, weakened by salt and serum, can rupture human red blood cells (hemolysis), and is expensive to make. Turning it into a therapeutic means engineering around all of that.
This unit surveys the obstacles and the strategies: shorter and modified analogs, D-amino-acid and stabilized designs, nanoparticle and hydrogel delivery, fusion constructs, and where the whole pipeline actually stands. It is the practical bridge between LL-37 biology and any real-world use.